Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5-[(2S,3R)-1-(3-chloro-4-cyanophenyl)-3-hydroxy-2-methylpyrrolidin-3-yl]-N,N-dimethylpyridine-2-carboxamide
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 PubChem ID
CID: 70960796
SID: 163495946
Canonical SMILES
C[C@@H]1N(CC[C@@]1(O)c1ccc(nc1)C(=O)N(C)C)c1ccc(C#N)c(Cl)c1
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Compound Formula C20H21ClN4O2
Compound Structure
Protein Name
 Protein Info 
Androgen receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 4
Uniprot ID
P10275
Gene Name
AR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  2
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
2
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CL000742 FreeStyle 293-F
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
2
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CL000888 LNCaP-hr
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS