Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]phenyl}-4,5-dimethoxy-2-(3-quinolylcarboxamido)benzamide
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 PubChem ID
CID: 148201
SID: 14765736
Canonical SMILES
COc1cc2CCN(CCc3ccc(NC(=O)c4cc(OC)c(OC)cc4NC(=O)c4cnc5ccccc5c4)cc3)Cc2cc1OC
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Compound Formula C38H38N4O6
Compound Structure
Protein Name
 Protein Info 
ATP-dependent translocase ABCB1
Protein Classification
Transporter
>
Primary active transporter
>
ATP-binding cassette
>
ABCB subfamily
Uniprot ID
P08183
Gene Name
ABCB1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000072 A2780
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 72.44 nM
   TI
   LI
   LO
   TS
2
IC50 = 125.89 nM
   TI
   LI
   LO
   TS
CL000135 A2780ADR
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 78 nM
   TI
   LI
   LO
   TS
CL000357 CEM/VLB500
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 68 nM
   TI
   LI
   LO
   TS
CL000137 K562/A02
 Cell Line Info 
Homo sapiens (Human)  7
1
IC50 = 460 nM
   TI
   LI
   LO
   TS
2
IC50 = 1600 nM
   TI
   LI
   LO
   TS
3
IC50 = 1970 nM
   TI
   LI
   LO
   TS
4
IC50 = 3020 nM
   TI
   LI
   LO
   TS
5
IC50 = 4970 nM
   TI
   LI
   LO
   TS
6
IC50 = 8280 nM
   TI
   LI
   LO
   TS
7
IC50 = 14390 nM
   TI
   LI
   LO
   TS
CL000356 KB-V1
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 223 nM
   TI
   LI
   LO
   TS
2
IC50 = 356 nM
   TI
   LI
   LO
   TS
CL000031 MDCK
 Cell Line Info 
Canis lupus familiaris (Dog)  2
1
EC50 = 44 nM
   TI
   LI
   LO
   TS
2
IC50 = 210 nM
   TI
   LI
   LO
   TS
CL000355 MES-SA/Dx5
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 16 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
EC50 = 211 nM
   TI
   LI
   LO
   TS
2
IC50 >= 1180 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 32.7 nM