Brief Information of the Compound and Protein
Compound Name
 Compound Info 
7-[3-[4-(2,3-dichlorophenyl)-1,4-diazepan-1-yl]propoxy]-3,4-dihydro-2H-isoquinolin-1-one
    Show/Hide
 PubChem ID
CID: 66559587
SID: 152190101
Canonical SMILES
Clc1cccc(N2CCCN(CCCOc3ccc4CCNC(=O)c4c3)CC2)c1Cl
    Show/Hide
Compound Formula C23H27Cl2N3O2
Compound Structure
Protein Name
 Protein Info 
D(2) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P14416
Gene Name
DRD2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 5.7 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 5.6 nM
   TI
   LI
   LO
   TS
CL000883 HTLA
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 6.3 nM
   TI
   LI
   LO
   TS
2
EC50 = 8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 5.7 nM