Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

5-(4-chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1H-pyrazole-3-carboxylic acid (1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amide

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PubChem ID

CID: 44208932

Canonical SMILES	Cc1ccc(Cn2nc(cc2-c2ccc(Cl)c(C)c2)C(=O)NC2C3(C)CCC(C3)C2(C)C)cc1 Show/Hide
Compound Formula	C29H34ClN3O

Compound Structure

Protein Name

Protein Info

Cannabinoid receptor 2

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Lipid-like ligand receptor (family A GPCR)

Cannabinoid receptor

Uniprot ID

P34972

Gene Name

CNR2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	13
1	EC50 = 1.8 nM	TI LI LO TS
2	EC50 = 2.1 nM	TI LI LO TS
3	EC50 = 10.4 nM	TI LI LO TS
4	EC50 = 13.71 nM	TI LI LO TS
5	EC50 = 14 nM	TI LI LO TS
6	EC50 = 153.8 nM	TI LI LO TS
7	IC50 = 3.162 nM	TI LI LO TS
8	Ki = 0.6 nM	TI LI LO TS
9	Ki = 2.1 nM	TI LI LO TS
10	Ki = 18.65 nM	TI LI LO TS
11	Ki = 21 nM	TI LI LO TS
12	Ki = 21.6 nM	TI LI LO TS
13	Ki = 51.7 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	3
1	EC50 = 11.5 nM	TI LI LO TS
2	Ki = 0.6 nM	TI LI LO TS
3	Ki = 5.4 nM	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	EC50 = 741.31 nM	TI LI LO TS

Biochemical Assays