Brief Information of the Compound and Protein
Compound Name
5-[2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine
    Show/Hide
PubChem ID
CID: 46927938
SID: 99433726
Canonical SMILES
CS(=O)(=O)N1CCN(Cc2cn3cc(nc(N4CCOCC4)c3n2)-c2cnc(N)nc2)CC1
    Show/Hide
Compound Formula C20H27N9O3S
Compound Structure
Protein Name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Protein Classification
Enzyme
>
Transferase
Uniprot ID
P42336
Gene Name
PIK3CA
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000043 U2OS Homo sapiens (Human)  1
1
IC50 = 8.3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1.77 nM
2 Ki = 1.89 nM
3 Ki = 2.33 nM