Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate

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PubChem ID

CID: 5283560

SID: 99431555

Canonical SMILES	CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O Show/Hide
Compound Formula	C18H38NO5P

Compound Structure

Protein Name

Protein Info

Sphingosine 1-phosphate receptor 1

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Lipid-like ligand receptor (family A GPCR)

EDG receptor

Uniprot ID

P21453

Gene Name

S1PR1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	EC50 = 0.55 nM	TI LI LO TS
2	IC50 = 0.16 nM	TI LI LO TS
3	IC50 = 0.67 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 = 1.4 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	5
1	EC50 = 0.9 nM	TI LI LO TS
2	EC50 = 4.5 nM	TI LI LO TS
3	EC50 = 5.6 nM	TI LI LO TS
4	EC50 = 20 nM	TI LI LO TS
5	IC50 = 0.78 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 0.1 nM	TI LI LO TS
2	EC50 = 25.3 nM	TI LI LO TS
CL000043	U2OS Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 2.8 nM	TI LI LO TS
2	EC50 = 18 nM	TI LI LO TS

Biochemical Assays