Brief Information of the Compound and Protein
Compound Name
2-(difluoromethyl)-3-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-7-methoxybenzimidazol-5-amine
    Show/Hide
PubChem ID
CID: 56589559
SID: 134216685
Canonical SMILES
COc1cc(N)cc2n(c(nc12)C(F)F)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1
    Show/Hide
Compound Formula C20H24F2N8O3
Compound Structure
Protein Name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Protein Classification
Enzyme
>
Transferase
Uniprot ID
P42336
Gene Name
PIK3CA
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000102 U-87MG ATCC Homo sapiens (Human)  2
1
IC50 = 4.8 nM
   TI
   LI
   LO
   TS
2
IC50 = 8.8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.95 nM
2 IC50 = 1 nM
3 IC50 = 3.1 nM