Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

BUPRENORPHINE

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PubChem ID

CID: 9848990

SID: 14882841

Canonical SMILES	CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45 Show/Hide
Compound Formula	C29H41NO4

Compound Structure

Protein Name

Protein Info

Mu-type opioid receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Peptide receptor (family A GPCR)

Short peptide receptor (family A GPCR)

Opioid receptor

Uniprot ID

P35372

Gene Name

OPRM1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	8
1	EC50 = 0.11 nM	TI LI LO TS
2	EC50 = 2.3 nM	TI LI LO TS
3	EC50 = 10.2 nM	TI LI LO TS
4	EC50 = 14.8 nM	TI LI LO TS
5	IC50 = 0.59 nM	TI LI LO TS
6	Ki = 0.09 nM	TI LI LO TS
7	Ki = 0.21 nM	TI LI LO TS
8	Ki = 1.5 nM	TI LI LO TS
CL000386	Flp-In-CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 1.585 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 1.995 nM	TI LI LO TS

Biochemical Assays

1	Ki = 1.5 nM