Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide
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 PubChem ID
CID: 5494449
SID: 26683796
Canonical SMILES
CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1
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Compound Formula C23H28N8OS
Compound Structure
Protein Name
 Protein Info 
Aurora kinase B
Protein Classification
Enzyme
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Kinase
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Protein Kinase
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Other protein kinase group
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Other protein kinase AUR family
Uniprot ID
Q96GD4
Gene Name
AURKB
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 55 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 14.7 nM
2 IC50 = 15.7 nM
3 IC50 = 17 nM
4 IC50 = 18 nM
5 IC50 = 18.6 nM
6 IC50 = 30 nM
7 IC50 = 40 nM
8 IC50 = 43 nM
9 IC50 = 68 nM
10 Kd = 7 nM
11 Kd = 7.4 nM
12 Ki = 1.8 nM
13 Ki = 3.36 nM
14 Ki = 18 nM