Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-(4-Methylpiperazin-1-yl)-6-pyrrolidin-1-ylpyrimidin-2-ylamine
    Show/Hide
 PubChem ID
CID: 25130912
SID: 56455290
Canonical SMILES
CN1CCN(CC1)c1cc(nc(N)n1)N1CCCC1
    Show/Hide
Compound Formula C13H22N6
Compound Structure
Protein Name
 Protein Info 
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Kd = 1.995 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 6 nM