Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US8987315, Ketoconazole
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 PubChem ID
CID: 3823
Canonical SMILES
CC(=O)N1CCN(CC1)c1ccc(OCC2COC(Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1
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Compound Formula C26H28Cl2N4O4
Compound Structure
Protein Name
 Protein Info 
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Protein Classification
Enzyme
>
Cytochrome P450
>
Cytochrome P450 family 24
>
Cytochrome P450 family 24A
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Cytochrome P450 24A1
Uniprot ID
Q07973
Gene Name
CYP24A1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 520 nM
   TI
   LI
   LO
   TS
CL000191 V79
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
IC50 = 312 nM
   TI
   LI
   LO
   TS
2
IC50 = 520 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 470 nM
2 IC50 = 500 nM
3 Ki = 35 nM