Brief Information of the Compound and Protein
Compound Name
1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[3-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea
    Show/Hide
PubChem ID
CID: 46900426
SID: 99353790
Canonical SMILES
Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cccc(Oc2ccnc3[nH]c(=O)cnc23)c1)C(C)(C)C
    Show/Hide
Compound Formula C28H27N7O3
Compound Structure
Protein Name
Serine/threonine-protein kinase B-raf
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P15056
Gene Name
BRAF
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000252 WM266-4 Homo sapiens (Human)  1
1
IC50 = 274 nM
   TI
   LI
   LO
   TS