Brief Information of the Compound and Protein
Compound Name
1-(4-bromophenyl)-5-[2-(2,2-dimethylpropanoylamino)-4-methyl-1,3-thiazol-5-yl]-N-(4-methoxyphenyl)pyrazole-3-carboxamide
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PubChem ID
CID: 46221405
SID: 96076017
Canonical SMILES
COc1ccc(NC(=O)c2cc(-c3sc(NC(=O)C(C)(C)C)nc3C)n(n2)-c2ccc(Br)cc2)cc1
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Compound Formula C26H26BrN5O3S
Compound Structure
Protein Name
Cystic fibrosis transmembrane conductance regulator
Protein Classification
Ion channel
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Other ion channel
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Chloride channel
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Cystic fibrosis transmembrane conductance regulator
Uniprot ID
P13569
Gene Name
CFTR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000535 CFBE41o- Homo sapiens (Human)  1
1
EC50 = 3388.44 nM
   TI
   LI
   LO
   TS
CL000259 FRT Rattus norvegicus (Rat)  1
1
EC50 = 3400 nM
   TI
   LI
   LO
   TS