Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-2-carboxamide
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 PubChem ID
CID: 10476504
SID: 15500266
Canonical SMILES
COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1
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Compound Formula C23H29N5O2
Compound Structure
Protein Name
 Protein Info 
D(3) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P35462
Gene Name
DRD3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  4
1
EC50 = 1.4 nM
   TI
   LI
   LO
   TS
2
Ki = 3.5 nM
   TI
   LI
   LO
   TS
3
Ki = 4.266 nM
   TI
   LI
   LO
   TS
4
Ki = 4.3 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  8
1
Ki = 7.4 nM
   TI
   LI
   LO
   TS
2
Ki = 7.6 nM
   TI
   LI
   LO
   TS
3
Ki = 93 nM
   TI
   LI
   LO
   TS
4
Ki = 97 nM
   TI
   LI
   LO
   TS
5
Ki = 130 nM
   TI
   LI
   LO
   TS
6
Ki = 290 nM
   TI
   LI
   LO
   TS
7
Ki = 340 nM
   TI
   LI
   LO
   TS
8
Ki = 500 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 4.3 nM