Brief Information of the Compound and Protein
Compound Name
BDBM50242742
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PubChem ID
CID: 16038120
SID: 24420733
Canonical SMILES
COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
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Compound Formula C30H40ClN7O3S
Compound Structure
Protein Name
ALK tyrosine kinase receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
Q9UM73
Gene Name
ALK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  2
1
IC50 = 3.7 nM
   TI
   LI
   LO
   TS
2
IC50 = 4 nM
   TI
   LI
   LO
   TS
CL000300 Karpas-299 Homo sapiens (Human)  1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CL000299 SU-DHL-1 Homo sapiens (Human)  1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 3 nM
2 IC50 = 0.15 nM
3 IC50 = 1.6 nM
4 IC50 = 3 nM
5 Kd = 1.1 nM