Brief Information of the Compound and Protein
Compound Name
(+/-)-5-fluoro-4-methyl-2-(2-methyl-4-(3-(tetrahydro-1H-pyrrolo[3,4-b]pyridin-6(2H,7H,7aH)-yl)propoxy)phenyl)-1H-benzo[d]imidazole
    Show/Hide
PubChem ID
CID: 46890590
Canonical SMILES
Cc1cc(OCCCN2CC3CCCNC3C2)ccc1-c1nc2ccc(F)c(C)c2[nH]1
    Show/Hide
Compound Formula C25H31FN4O
Compound Structure
Protein Name
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Kd = 50.12 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 42 nM