Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-(4,4-Spirohexyl-3,4-dihydro-1,3-dioxoisoquinolin-2(1H)-yl)benzonitrile
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 PubChem ID
CID: 44568123
Canonical SMILES
O=C1N(C(=O)C2(CCCCC2)c2ccccc12)c1ccc(cc1)C#N
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Compound Formula C21H18N2O2
Compound Structure
Protein Name
 Protein Info 
Progesterone receptor
Protein Classification
Transcription factor
>
Nuclear receptor
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Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 3
Uniprot ID
P06401
Gene Name
PGR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 450 nM
   TI
   LI
   LO
   TS
CL000078 T-47D
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 880 nM
   TI
   LI
   LO
   TS