Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-[2,2-di(phenyl)ethyl]amino]propoxy]phenyl]acetic acid
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 PubChem ID
CID: 447905
SID: 14911410
Canonical SMILES
OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c2ccccc2)Cc2cccc(c2Cl)C(F)(F)F)c1
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Compound Formula C33H31ClF3NO3
Compound Structure
Protein Name
 Protein Info 
Oxysterols receptor LXR-alpha
Protein Classification
Transcription factor
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Nuclear receptor
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Nuclear hormone receptor subfamily 1
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Nuclear hormone receptor subfamily 1 group H
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Nuclear hormone receptor subfamily 1 group H member 3
Uniprot ID
Q13133
Gene Name
NR1H3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
EC50 = 1300 nM
   TI
   LI
   LO
   TS
CL000044 CV-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  2
1
EC50 = 794.33 nM
   TI
   LI
   LO
   TS
2
IC50 = 100 nM
   TI
   LI
   LO
   TS
CL000148 Huh-7
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 660 nM
   TI
   LI
   LO
   TS
CL000004 SH-SY5Y
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 310 nM
   TI
   LI
   LO
   TS
CL000040 THP-1
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 97 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 22 nM
2 EC50 = 66 nM
3 EC50 = 80 nM
4 EC50 = 125 nM
5 EC50 = 190 nM
6 EC50 = 200 nM
7 EC50 = 280 nM
8 EC50 = 1128 nM
9 EC50 = 1300 nM
10 IC50 = 100 nM
11 IC50 = 235 nM
12 Kd = 6970 nM