Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-(2,4-dichlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid N-(tetrahydropyran-4-ylmethyl)amide
    Show/Hide
 PubChem ID
CID: 10253143
SID: 15256486
Canonical SMILES
FC(F)(F)c1nc(Nc2ccc(Cl)cc2Cl)ncc1C(=O)NCC1CCOCC1
    Show/Hide
Compound Formula C18H17Cl2F3N4O2
Compound Structure
Protein Name
 Protein Info 
Cannabinoid receptor 2
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
Cannabinoid receptor
Uniprot ID
P34972
Gene Name
CNR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  5
1
EC50 = 63 nM
   TI
   LI
   LO
   TS
2
EC50 = 342.8 nM
   TI
   LI
   LO
   TS
3
EC50 = 350 nM
   TI
   LI
   LO
   TS
4
EC50 = 431 nM
   TI
   LI
   LO
   TS
5
EC50 = 437 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
2
Ki > 5000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 50 nM