Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-(4-(1-(2-(6-methylpyridin-2-yl)ethyl)piperidine-4-carbonyl)phenyl)methanesulfonamide dihydrochloride
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 PubChem ID
CID: 3087190
SID: 14761046
Canonical SMILES
Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1.Cl.Cl
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Compound Formula C21H29Cl2N3O3S
Compound Structure
Protein Name
 Protein Info 
Potassium voltage-gated channel subfamily H member 2
Protein Classification
Ion channel
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Voltage-gated ion channel
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Potassium channels
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Voltage-gated potassium channel
Uniprot ID
Q12809
Gene Name
KCNH2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 89 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  7
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
2
IC50 = 500 nM
   TI
   LI
   LO
   TS
3
IC50 = 690 nM
   TI
   LI
   LO
   TS
4
IC50 = 2950 nM
   TI
   LI
   LO
   TS
5
IC50 = 6780 nM
   TI
   LI
   LO
   TS
6
Ki = 18.7 nM
   TI
   LI
   LO
   TS
7
Ki = 19.4 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 11 nM
2 IC50 = 18.1 nM