Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one
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 PubChem ID
CID: 60854
SID: 14782044
Canonical SMILES
Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12
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Compound Formula C21H21ClN4OS
Compound Structure
Protein Name
 Protein Info 
Potassium voltage-gated channel subfamily H member 2
Protein Classification
Ion channel
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Voltage-gated ion channel
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Potassium channels
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Voltage-gated potassium channel
Uniprot ID
Q12809
Gene Name
KCNH2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 120.23 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 152 nM
   TI
   LI
   LO
   TS
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 151.36 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 120.23 nM
2 IC50 = 125 nM
3 IC50 = 125.89 nM
4 IC50 < 1000 nM