Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl]-3-methoxy-piperidin-4-yl}-2-methoxy-benzamide

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PubChem ID

CID: 2769

SID: 14882747

Canonical SMILES	COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC Show/Hide
Compound Formula	C23H29ClFN3O4

Compound Structure

Protein Name

Protein Info

Potassium voltage-gated channel subfamily H member 2

Protein Classification

Ion channel

Voltage-gated ion channel

Potassium channels

Voltage-gated potassium channel

Uniprot ID

Q12809

Gene Name

KCNH2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	4
1	IC50 = 39.81 nM	TI LI LO TS
2	IC50 = 45 nM	TI LI LO TS
3	IC50 = 80 nM	TI LI LO TS
4	IC50 = 98 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	5
1	IC50 = 6.5 nM	TI LI LO TS
2	IC50 = 10 nM	TI LI LO TS
3	IC50 = 120 nM	TI LI LO TS
4	IC50 = 1710 nM	TI LI LO TS
5	IC50 = 2690 nM	TI LI LO TS
CL000083	MCF-7 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 6.457 nM	TI LI LO TS

Biochemical Assays