Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(5H,11H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-yl)-[2-chloro-4-(3-methyl-pyrazol-1-yl)-phenyl]-methanone
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 PubChem ID
CID: 5311500
SID: 12015369
Canonical SMILES
Cc1ccn(n1)-c1ccc(C(=O)N2Cc3cccn3Cc3ccccc23)c(Cl)c1
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Compound Formula C23H19ClN4O
Compound Structure
Protein Name
 Protein Info 
Vasopressin V2 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Vasopressin and oxytocin receptor
Uniprot ID
P30518
Gene Name
AVPR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
EC50 = 39.9 nM
   TI
   LI
   LO
   TS
2
Ki = 50 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 < 1 nM
   TI
   LI
   LO
   TS
CL000779 LV2
 Cell Line Info 
Mus musculus (Mouse)  3
1
EC50 = 0.74 nM
   TI
   LI
   LO
   TS
2
IC50 = 80 nM
   TI
   LI
   LO
   TS
3
IC50 = 80.3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 39.9 nM