Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
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 PubChem ID
CID: 442972
SID: 14928900
Canonical SMILES
C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C
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Compound Formula C27H41NO2
Compound Structure
Protein Name
 Protein Info 
Protein smoothened
Protein Classification
Membrane receptor
>
Frizzled family G protein-coupled receptor
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Smoothened receptor (frizzled family GPCR)
Uniprot ID
P56726
Gene Name
SMO
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CL001057 Ptch-deficient MEF
 Cell Line Info 
Mus musculus (Mouse)  2
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
2
IC50 = 1900 nM
   TI
   LI
   LO
   TS