Brief Information of the Compound and Protein
Compound Name
 Compound Info 
17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alpha,14-triol
    Show/Hide
 PubChem ID
CID: 5311304
SID: 14828107
Canonical SMILES
O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CCC1)c45
    Show/Hide
Compound Formula C21H27NO4
Compound Structure
Protein Name
 Protein Info 
Kappa-type opioid receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Opioid receptor
Uniprot ID
P41145
Gene Name
OPRK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  5
1
EC50 = 27 nM
   TI
   LI
   LO
   TS
2
EC50 = 56 nM
   TI
   LI
   LO
   TS
3
EC50 = 65 nM
   TI
   LI
   LO
   TS
4
Ki = 2.2 nM
   TI
   LI
   LO
   TS
5
Ki = 3 nM
   TI
   LI
   LO
   TS
CL000043 U2OS
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 250 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 83 nM
2 Ki = 29.95 nM