Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]-14-hydroxy-15-methyl-14-(prop-1-yn-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,6-dien-5-one

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PubChem ID

CID: 55245

SID: 12013919

Canonical SMILES	CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C Show/Hide
Compound Formula	C29H35NO2

Compound Structure

Protein Name

Protein Info

Progesterone receptor

Protein Classification

Transcription factor

Nuclear receptor

Nuclear hormone receptor subfamily 3

Nuclear hormone receptor subfamily 3 group C

Nuclear hormone receptor subfamily 3 group C member 3

Uniprot ID

P06401

Gene Name

PGR

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 = 0.4 nM	TI LI LO TS
CL000044	CV-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	7
1	EC50 = 0.3 nM	TI LI LO TS
2	EC50 > 10000 nM	TI LI LO TS
3	IC50 = 0.18 nM	TI LI LO TS
4	IC50 = 0.2512 nM	TI LI LO TS
5	IC50 = 0.3 nM	TI LI LO TS
6	IC50 = 0.6 nM	TI LI LO TS
7	Ki = 0.2512 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	Ki = 0.998 nM	TI LI LO TS
CL000332	T-47 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 2.6 nM	TI LI LO TS
CL000078	T-47D Cell Line Info	Homo sapiens (Human)	9
1	IC50 = 0.045 nM	TI LI LO TS
2	IC50 = 0.054 nM	TI LI LO TS
3	IC50 = 0.073 nM	TI LI LO TS
4	IC50 = 0.1 nM	TI LI LO TS
5	IC50 = 0.13 nM	TI LI LO TS
6	IC50 = 0.2 nM	TI LI LO TS
7	IC50 = 0.6 nM	TI LI LO TS
8	IC50 = 1.4 nM	TI LI LO TS
9	IC50 = 3.3 nM	TI LI LO TS

Biochemical Assays

1	Activity = 1.3 nM
2	IC50 = 2.9 nM
3	IC50 = 3 nM
4	IC50 = 7.943 nM
5	Ki = 0.58 nM
6	Ki = 0.64 nM
7	Ki = 1.1 nM
8	Ki = 10 nM
9	Ki = 15 nM

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About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han