Brief Information of the Compound and Protein
Compound Name
(2S,6R)-4-(8-Hydroxy-quinolin-5-yl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
    Show/Hide
PubChem ID
CID: 44389052
Canonical SMILES
O=C1[C@@H]2C3C=CC(C3)[C@@H]2C(=O)N1c1ccc(O)c2ncccc12
    Show/Hide
Compound Formula C18H14N2O3
Compound Structure
Protein Name
Androgen receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 4
Uniprot ID
P10275
Gene Name
AR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
Ki = 32 nM
   TI
   LI
   LO
   TS
CL000284 MDA-MB-453 Homo sapiens (Human)  2
1
IC50 = 418 nM
   TI
   LI
   LO
   TS
2
Ki = 162 nM
   TI
   LI
   LO
   TS
CL000807 MDA-PCa-2b Homo sapiens (Human)  1
1
IC50 = 3639 nM
   TI
   LI
   LO
   TS