Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
    Show/Hide
 PubChem ID
CID: 5280961
SID: 49684188
Canonical SMILES
Oc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O
    Show/Hide
Compound Formula C15H10O5
Compound Structure
Protein Name
 Protein Info 
Estrogen receptor beta
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group A
>
Nuclear hormone receptor subfamily 3 group A member 2
Uniprot ID
Q92731
Gene Name
ESR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1.3 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 19.95 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  3
1
EC50 = 4.1 nM
   TI
   LI
   LO
   TS
2
EC50 = 73 nM
   TI
   LI
   LO
   TS
3
EC50 = 956 nM
   TI
   LI
   LO
   TS
CL000111 MDA-MB-231
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 2.4 nM
   TI
   LI
   LO
   TS
CL000004 SH-SY5Y
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 1.7 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 6 nM
2 EC50 = 200 nM
3 IC50 = 4 nM
4 IC50 = 6.8 nM
5 IC50 = 9.7 nM
6 IC50 = 10 nM
7 IC50 = 18 nM
8 IC50 = 25 nM
9 IC50 = 61 nM
10 IC50 = 83 nM
11 IC50 = 98.7 nM
12 IC50 = 390 nM
13 IC50 = 395 nM
14 IC50 = 45900 nM
15 Ki = 24 nM