Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(1H-Indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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 PubChem ID
CID: 4060730
SID: 15949168
Canonical SMILES
CN1CCN(CC1)C(=O)c1cc2ccccc2[nH]1
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Compound Formula C14H17N3O
Compound Structure
Protein Name
 Protein Info 
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  3
1
Ki = 79.43 nM
   TI
   LI
   LO
   TS
2
Ki = 199.53 nM
   TI
   LI
   LO
   TS
3
Ki = 316.23 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 25.12 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
Ki = 138.04 nM
   TI
   LI
   LO
   TS
CL000074 SK-N-MC
 Cell Line Info 
Homo sapiens (Human)  3
1
Kd = 39.81 nM
   TI
   LI
   LO
   TS
2
Ki = 17 nM
   TI
   LI
   LO
   TS
3
Ki = 25.12 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 17 nM
2 Ki = 38 nM