Brief Information of the Compound and Protein
Compound Name
 Compound Info 
METHIOTHEPIN
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 PubChem ID
CID: 4106
SID: 12012717
Canonical SMILES
CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1
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Compound Formula C20H24N2S2
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 6
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P50406
Gene Name
HTR6
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 0.9 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
IC50 = 4.7 nM
   TI
   LI
   LO
   TS
2
Ki = 0.9333 nM
   TI
   LI
   LO
   TS
3
Ki = 1 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 4.1 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 127 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.4 nM
2 Ki = 0.4 nM