Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(-)-(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(pyridin-3-ylmethyl)-2-(4-(trifluoromethoxy)phenyl)acetamide

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PubChem ID

CID: 24957182

SID: 56255027

Canonical SMILES	CCOc1ccc(cc1)-n1c(nc2ncccc2c1=O)[C@@H](C)N(Cc1cccnc1)C(=O)Cc1ccc(OC(F)(F)F)cc1 Show/Hide
Compound Formula	C32H28F3N5O4

Compound Structure

Protein Name

Protein Info

C-X-C chemokine receptor type 3

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Peptide receptor (family A GPCR)

Chemokine receptor

CXC chemokine receptor

Uniprot ID

P49682

Gene Name

CXCR3

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 = 330 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	2
1	Ki = 39.81 nM	TI LI LO TS
2	Ki = 158.49 nM	TI LI LO TS

Biochemical Assays