Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-2-yl)propylamino)-3,4-dioxocyclobut-1-enylamino)benzamide
    Show/Hide
 PubChem ID
CID: 9865554
SID: 49684245
Canonical SMILES
CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(C)o1
    Show/Hide
Compound Formula C21H23N3O5
Compound Structure
Protein Name
 Protein Info 
C-X-C chemokine receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CXC chemokine receptor
Uniprot ID
P25024
Gene Name
CXCR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 36 nM
   TI
   LI
   LO
   TS
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 18 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
2
IC50 = 198.3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3.9 nM
2 Ki = 20 nM