Brief Information of the Compound and Protein
Compound Name
 Compound Info 
7-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]oxazepine
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 PubChem ID
CID: 11846300
SID: 17159067
Canonical SMILES
CN1CCN(CC1)C1=Nc2ccc(Cl)cc2Oc2ccccc12
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Compound Formula C18H18ClN3O
Compound Structure
Protein Name
 Protein Info 
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 25.12 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
Ki = 6 nM
   TI
   LI
   LO
   TS
2
Ki = 28.18 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
Ki = 102.33 nM
   TI
   LI
   LO
   TS
CL000074 SK-N-MC
 Cell Line Info 
Homo sapiens (Human)  6
1
EC50 = 19.95 nM
   TI
   LI
   LO
   TS
2
Kd = 10.7 nM
   TI
   LI
   LO
   TS
3
Kd = 13 nM
   TI
   LI
   LO
   TS
4
Kd = 22.2 nM
   TI
   LI
   LO
   TS
5
Kd = 72 nM
   TI
   LI
   LO
   TS
6
Ki = 28.18 nM
   TI
   LI
   LO
   TS