Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide

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PubChem ID

CID: 448222

SID: 14849888

Canonical SMILES	CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 Show/Hide
Compound Formula	C12H16N6O4

Compound Structure

Protein Name

Protein Info

Adenosine receptor A2b

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Nucleotide-like receptor (family A GPCR)

Adenosine receptor

Uniprot ID

P29275

Gene Name

ADORA2B

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	11
1	EC50 = 38 nM	TI LI LO TS
2	EC50 = 104 nM	TI LI LO TS
3	EC50 = 155 nM	TI LI LO TS
4	EC50 = 160 nM	TI LI LO TS
5	EC50 = 440 nM	TI LI LO TS
6	EC50 = 1510 nM	TI LI LO TS
7	EC50 = 2400 nM	TI LI LO TS
8	EC50 = 3630.78 nM	TI LI LO TS
9	EC50 > 10000 nM	TI LI LO TS
10	Ki = 1270 nM	TI LI LO TS
11	Ki = 1890 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	EC50 = 63.1 nM	TI LI LO TS
2	EC50 = 3100 nM	TI LI LO TS
CL000386	Flp-In-CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	4
1	EC50 = 3.162 nM	TI LI LO TS
2	EC50 = 4.786 nM	TI LI LO TS
3	EC50 = 15.85 nM	TI LI LO TS
4	EC50 = 42.66 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	4
1	Ki = 262 nM	TI LI LO TS
2	Ki = 570 nM	TI LI LO TS
3	Ki = 760 nM	TI LI LO TS
4	Ki = 884 nM	TI LI LO TS

Biochemical Assays

1	EC50 = 330 nM