Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-yl}-1-oxopropan-2-yl]carbamoyl}-1-methylethan-1-aminium
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 PubChem ID
CID: 178024
SID: 14763096
Canonical SMILES
CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CN(c3ccccc23)S(C)(=O)=O)CC1
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Compound Formula C27H36N4O5S
Compound Structure
Protein Name
 Protein Info 
Growth hormone secretagogue receptor type 1
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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GRP-related receptor
Uniprot ID
Q92847
Gene Name
GHSR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 1.43 nM
   TI
   LI
   LO
   TS
CL000009 LLC-PK1
 Cell Line Info 
Sus scrofa (Pig)  1
1
IC50 = 0.76 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Activity = 0.3 nM
2 EC50 = 0.1995 nM
3 IC50 = 0.4 nM
4 IC50 = 0.63 nM
5 IC50 = 32 nM
6 IC50 = 300 nM
7 Kd = 0.14 nM
8 Ki = 0.24 nM