Brief Information of the Compound and Protein
Compound Name
 Compound Info 
ATROPEN
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 PubChem ID
SID: 16376693
Canonical SMILES
CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c1ccccc1
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Compound Formula C17H23NO3
Compound Structure
Protein Name
 Protein Info 
Muscarinic acetylcholine receptor M2
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Acetylcholine receptor
Uniprot ID
P08172
Gene Name
CHRM2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
Ki = 0.9 nM
   TI
   LI
   LO
   TS
2
Ki = 1.5 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
Ki = 1.44 nM
   TI
   LI
   LO
   TS
2
Ki = 1.9 nM
   TI
   LI
   LO
   TS
3
Ki = 15.85 nM
   TI
   LI
   LO
   TS
CL000845 CHO-K9
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  7
1
Ki = 0.8128 nM
   TI
   LI
   LO
   TS
2
Ki = 0.912 nM
   TI
   LI
   LO
   TS
3
Ki = 2.512 nM
   TI
   LI
   LO
   TS
4
Ki = 3.162 nM
   TI
   LI
   LO
   TS
5
Ki = 4.898 nM
   TI
   LI
   LO
   TS
6
Ki = 7.079 nM
   TI
   LI
   LO
   TS
7
Ki = 18.62 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 8.128 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.344 nM
2 Ki = 1 nM