Brief Information of the Compound and Protein
Compound Name
 Compound Info 
9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine
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 PubChem ID
CID: 2690
SID: 15071946
Canonical SMILES
Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
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Compound Formula C13H8ClN5O
Compound Structure
Protein Name
 Protein Info 
Adenosine receptor A3
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
>
Nucleotide-like receptor (family A GPCR)
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Adenosine receptor
Uniprot ID
P0DMS8
Gene Name
ADORA3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
IC50 = 406 nM
   TI
   LI
   LO
   TS
2
Ki = 85 nM
   TI
   LI
   LO
   TS
3
Ki = 84918.05 nM
   TI
   LI
   LO
   TS
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  2
1
Ki = 253 nM
   TI
   LI
   LO
   TS
2
Ki = 3260 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  4
1
Ki = 13.8 nM
   TI
   LI
   LO
   TS
2
Ki = 14 nM
   TI
   LI
   LO
   TS
3
Ki = 140 nM
   TI
   LI
   LO
   TS
4
Ki = 143 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 85 nM
2 Ki = 95 nM