Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

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PubChem ID

CID: 36511

SID: 14890642

Canonical SMILES	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O Show/Hide
Compound Formula	C63H98N18O13S

Compound Structure

Protein Name

Protein Info

Substance-P receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Peptide receptor (family A GPCR)

Short peptide receptor (family A GPCR)

Neurokinin receptor

Uniprot ID

P25103

Gene Name

TACR1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	4
1	IC50 = 1.4 nM	TI LI LO TS
2	IC50 = 1.5 nM	TI LI LO TS
3	IC50 = 1.7 nM	TI LI LO TS
4	Ki = 1.6 nM	TI LI LO TS
CL000880	COS Cell Line Info	Chlorocebus aethiops (Green monkey)	2
1	IC50 = 0.9 nM	TI LI LO TS
2	IC50 = 1.1 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 0.6 nM	TI LI LO TS
CL000228	IM-9 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 0.61 nM	TI LI LO TS
CL000441	UC-11MG Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 0.12 nM	TI LI LO TS