Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(4S,5S)-5-(3-Fluoro-phenyl)-2,2,4-trimethyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one
    Show/Hide
 PubChem ID
CID: 10596379
SID: 15625626
Canonical SMILES
C[C@@H]1C(=O)C(C)(C)Nc2ccc3-c4ccccc4O[C@@H](c4cccc(F)c4)c3c12
    Show/Hide
Compound Formula C25H22FNO2
Compound Structure
Protein Name
 Protein Info 
Progesterone receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 3
Uniprot ID
P06401
Gene Name
PGR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
EC50 = 6.3 nM
   TI
   LI
   LO
   TS
CL000078 T-47D
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 14.8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 2.6 nM