Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)
    Show/Hide
 PubChem ID
CID: 3559
SID: 14902191
Canonical SMILES
OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
    Show/Hide
Compound Formula C21H23ClFNO2
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 2A
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P28223
Gene Name
HTR2A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000234 AU-BEK
 Cell Line Info 
Bos taurus (Bovine)  2
1
IC50 = 288 nM
   TI
   LI
   LO
   TS
2
Ki = 108 nM
   TI
   LI
   LO
   TS
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
Ki = 22.91 nM
   TI
   LI
   LO
   TS
2
Ki = 89 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 25 nM
2 Ki = 100 nM
3 Ki = 120 nM
4 Ki = 130 nM
5 Ki = 165.96 nM
6 Ki = 435 nM