Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one
    Show/Hide
 PubChem ID
CID: 57363
SID: 12014292
Canonical SMILES
CC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C
    Show/Hide
Compound Formula C23H36N2O2
Compound Structure
Protein Name
 Protein Info 
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Protein Classification
Enzyme
>
Oxidoreductase
Uniprot ID
P31213
Gene Name
SRD5A2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000119 DU145
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 42 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 30.3 nM
   TI
   LI
   LO
   TS
2
IC50 = 40 nM
   TI
   LI
   LO
   TS
3
IC50 = 60 nM
   TI
   LI
   LO
   TS
CL000420 SW13
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 4.53 nM
   TI
   LI
   LO
   TS
2
IC50 = 8.47 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 < 0.1 nM
2 IC50 = 0.18 nM
3 IC50 = 3 nM
4 IC50 = 4.2 nM
5 IC50 = 5 nM
6 IC50 = 8.5 nM
7 IC50 = 10 nM
8 IC50 = 58 nM
9 Ki = 2 nM