Brief Information of the Compound and Protein
Compound Name
2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
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PubChem ID
CID: 126941
SID: 14760074
Canonical SMILES
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
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Compound Formula C20H22N8O5
Compound Structure
Protein Name
Dihydrofolate reductase
Protein Classification
Enzyme
>
Oxidoreductase
Uniprot ID
P00375
Gene Name
DHFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000266 L1210 Mus musculus (Mouse)  3
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
2
IC50 = 45 nM
   TI
   LI
   LO
   TS
3
Ki = 3900 nM
   TI
   LI
   LO
   TS
CL000343 L1210/R81 Mus musculus (Mouse)  1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CL000342 P388 Mus musculus (Mouse)  1
1
IC50 = 6.6 nM
   TI
   LI
   LO
   TS