General Information of the Cell Line
Cell Line ID
CL000342
Cell Line Name
P388
Synonyms
P-388
Category
Cancer cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_7222
Disease
Mouse lymphoma (NCIt: C21602)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT02055, Dihydrofolate reductase
 Protein Info 
Compound ID Compound Name Compound Formula
CP0394423
 Compound Info 
2-{4-[2-(2-Amino-4-hydroxy-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid
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C21H24N4O6
  1
1
IC50 = 2.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036197
 Compound Info 
2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
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C20H22N8O5
  1
1
IC50 = 6.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0438355
 Compound Info 
2-{4-[3-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-propyl]-benzoylamino}-pentanedioic acid
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C22H27N5O5
  1
1
IC50 = 7.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0238793
 Compound Info 
(S)-2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid
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C22H25N7O5
  1
1
IC50 = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0540907
 Compound Info 
2-{4-[3-(2-Amino-4-hydroxy-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-propyl]-benzoylamino}-pentanedioic acid
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C22H26N4O6
  1
1
IC50 = 60 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463754
 Compound Info 
2-{4-[2-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid
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C21H25N5O5
  1
1
IC50 = 72 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0238793
 Compound Info 
(S)-2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid
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 C22H25N7O5  1
1
IC50 = 4.3 nM
   TI
   LI
   LO
   TS
CP0394423
 Compound Info 
2-{4-[2-(2-Amino-4-hydroxy-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid
   Show/Hide
 C21H24N4O6  1
1
IC50 > 1 nM
   TI
   LI
   LO
   TS
CP0438355
 Compound Info 
2-{4-[3-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-propyl]-benzoylamino}-pentanedioic acid
   Show/Hide
 C22H27N5O5  1
1
IC50 = 2.5 nM
   TI
   LI
   LO
   TS
CP0540907
 Compound Info 
2-{4-[3-(2-Amino-4-hydroxy-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-propyl]-benzoylamino}-pentanedioic acid
   Show/Hide
 C22H26N4O6  1
1
IC50 > 1 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line