General Information of the Protein
Protein ID
PT07525
Protein Name
RNA-binding protein FXR2
Secondarily
Protein Name
FMR1 autosomal homolog 2
Gene Name
FXR2
Secondarily
Gene Name
FMR1L2
Sequence
MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGGRGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPPLERTKPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSMVNGVS
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity).
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Uniprot ID
Primary ID:
P51116

Secondarily ID:
B2R9M2
D3DTQ1
Q86V09
Q8WUM2
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Ensembl ID
ENSG00000129245
HGNC ID
HGNC:4024
Subcellular Location
Cytoplasm
Cytoplasmic ribonucleoprotein granule
Cytoplasm
Postsynapse
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000148 , Huh-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0545451
 Compound Info 
6-[2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]-7-azaspiro[3.5]non-2-en-7-yl]-4-(trifluoromethyl)quinoline-2-carboxylic acid
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C30H23Cl2F3N4O3
  2
1
EC50 = 243 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 281 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0550462
 Compound Info 
CHEMBL5182534
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C35H41F4N3O4
  2
1
EC50 = 389 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 > 40000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info