General Information of the Protein
Protein ID
PT07431
Protein Name
Sodium-dependent phosphate transport protein 2C
Secondarily
Protein Name
Na(+)-dependent phosphate cotransporter 2C
Sodium/phosphate cotransporter 2C
Solute carrier family 34 member 3
Gene Name
SLC34A3
Secondarily
Gene Name
Npt2c
Sequence
MPNSLAGGQVPNPTLDAFDLVDRSLRNAGISGSIPGLEEGGTDPWTFSPLKNADQLKEVGMASRLRRVVSSFLKACGLLGSLYFFICSLDILSSAFQLLGSKMAGDIFKDNVVLSNPVAGLVIGVLVTVLVQSSSTSSSIVVSMVASKLLTVQVSVPIIMGVNVGTSITSTLVSMAQSGDRDEFQRAFSGSAVHGIFNWLTVLVLLPLESATAALERLSELALGAASLQPGQQAPDILKALTRPFTHLIIQLDSSVITSGITSNTTNSSLIKHWCGFRGETPQGSSEGCGLFSSCTERNSSASPEEDRLLCHHLFAGSKLTDLAVGFILLAGSLLVLCVCLVLIVKLLNSVLKGRIAQAVKTVINADFPFPFGWLSGYLAILVGAGLTFLLQSSSVFTAAIVPLMGVGVIDLERAYPLFLGSNIGTTTTALLAALASPADMLIFAVQVALIHFFFNLAGILLWYLVPVLRLPIPLAKRFGNLTAQYRWVAIVYLLLTFLLLPLAAFGLSLAGGTVLAAVGGPLVGLVLLIILVNVLQQHRPSWLPRCLQSWAWLPLWLHSLEPWDRLVTACCPCRACSNSPMTSKVAHCYENPQVIASQQL
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Organism
Mus musculus, Mouse
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC34 family of sodium phosphate co-transporters
Function
Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:12690469, PubMed:16113079). The cotransport has a Na(+):Pi stoichiometry of 2:1 and is electroneutral (PubMed:16113079).
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Uniprot ID
Primary ID:
Q80SU6

Secondarily ID:
Q05AC3
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Ensembl ID
ENSG00000198569
Subcellular Location
Apical cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0432155
 Compound Info 
3-chloro-7-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
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C15H14ClF3N4O2
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT07698 Sodium-dependent phosphate transport protein 2C Rattus norvegicus, Rat
 Protein Info