General Information of the Protein
Protein ID
PT07381
Protein Name
Alpha-1-antitrypsin-related protein
Secondarily
Protein Name
Protease inhibitor 1-like
Serpin A2
Gene Name
SERPINA2
Secondarily
Gene Name
ARGS
ATR
PIL
SERPINA2P
Sequence
MPFSVSWGILLLAGLCCLVPSSLVEDPQEDAAQKTDTSHHDQGDWEDLACQKISYNVTDLAFDLYKELADLSQTSNVLVTPTSVAMAFAMLSLGTKADTRTEILEGLNVNLTETPEAKIHECFQQVLQALSRPDTRLQLTTGSSLFVNKSMKLVDTFLEDTKKLYHSEASSINFRDTEEAKEQINNYVEKRTGRKVVDLVKHLKKDTSLALVDYISFHGKWKDKFKAEHIMVEGFHVDDKTIIRVPMINHLGRFDIHRDRELSSWVLAQHYVGNATAFFILPDPKKMWQLEEKLTYSHLENIQRAFDIRSINLHFPKLSISGTYKLKRVLRNLGITKIFSNEADLSGVSQEAPLKLSKAVHVAVLTIDEKGTEATGAPHLEEKAWSKYQTVMFNRPFLVIIKDDITNFPLFIGKVVNPTQK
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Putative serine protease inhibitor.
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Uniprot ID
Primary ID:
P20848

Secondarily ID:
A0A0G2JPK4
S4UD68
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HGNC ID
HGNC:8985
Subcellular Location
Endoplasmic reticulum
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000007 , HT-29
Compound ID Compound Name Compound Formula
CP0014710
1-(cyclohexen-1-yl)-8-[5-(difluoromethyl)pyridin-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline
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C21H17F2N5
 1
1
IC50 = 641 nM
   TI
   LI
   LO
   TS
CP0013685
8-[5-(difluoromethyl)pyridin-3-yl]-1-(2,3,6,7-tetrahydrooxepin-4-yl)-[1,2,4]triazolo[4,3-a]quinoxaline
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C21H17F2N5O
 1
1
IC50 = 2360 nM
   TI
   LI
   LO
   TS
CP0014718
1-(cyclohepten-1-yl)-8-[5-(difluoromethyl)pyridin-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline
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C22H19F2N5
 1
1
IC50 = 2890 nM
   TI
   LI
   LO
   TS
CP0014706
8-[5-(difluoromethyl)pyridin-3-yl]-1-(3,6-dihydro-2H-pyran-4-yl)-[1,2,4]triazolo[4,3-a]quinoxaline
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C20H15F2N5O
 1
1
IC50 = 4080 nM
   TI
   LI
   LO
   TS
CP0013686
8-[5-(difluoromethyl)pyridin-3-yl]-1-(4-methoxycyclohexyl)-[1,2,4]triazolo[4,3-a]quinoxaline
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C22H21F2N5O
 1
1
IC50 = 6000 nM
   TI
   LI
   LO
   TS
CP0014320
CHEMBL4871998
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C21H17F2N5
 1
1
IC50 = 6160 nM
   TI
   LI
   LO
   TS
CP0005823
CHEMBL4873263
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C20H15F2N5O
 1
1
IC50 = 8300 nM
   TI
   LI
   LO
   TS
CP0003520
8-[5-(difluoromethyl)pyridin-3-yl]-1-(4-methoxycyclohexyl)-[1,2,4]triazolo[4,3-a]quinoxaline
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C22H21F2N5O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0014701
8-[5-(difluoromethyl)pyridin-3-yl]-1-(oxan-4-yl)-[1,2,4]triazolo[4,3-a]quinoxaline
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C20H17F2N5O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS