General Information of the Protein
Protein ID
PT07282
Protein Name
Protein Wiz
Secondarily
Protein Name
Widely-interspaced zinc finger-containing protein
Zinc finger protein 803
Gene Name
WIZ
Secondarily
Gene Name
ZNF803
Sequence
MEGSLAGSLAAPDRPQGPERLPGPAPRENIEGGAEAAEGEGGIFRSTRYLPVTKEGPRDILDGRGGISGTPDGRGPWEHPLVQEAGEGILSERRFEDSVIVRTMKPHAELEGSRRFLHHRGEPRLLEKHAQGRPRFDWLQDEDEQGSPQDAGLHLDLPAQPPPLAPFRRVFVPVEDTPKTLDMAVVGGREDLEDLEGLAQPSEWGLPTSASEVATQTWTVNSEASVERLQPLLPPIRTGPYLCELLEEVAEGVASPDEDEDEEPAVFPCIECSIYFKQKEHLLEHMSQHRRAPGQEPPADLAPLACGECGWAFADPTALEQHRQLHQASREKIIEEIQKLKQVPGDEGREARLQCPKCVFGTNSSRAYVQHAKLHMREPPGQTTKEPFGGSSGAGSPSPEASALLYQPYGAAVGLSACVFCGFPAPSESLLREHVRLVHAHPHWEEDGEAYEEDPASQPGTSQDAHACFPDTAVDYFGKAEPSLAPMWRENPAGYDPSLAFGPGCQQLSIRDFPLSKPLLHGTGQRPLGRLAFPSTLASTPYSLQLGRNKSTVHPQGLGERRRPWSEEEEEEEEEEDVVLTSEMDFSPENGVFSPLATPSLIPQAALELKQAFREALQAVEATQGQQQQLRGMVPIVLVAKLGPQVMAAARVPPRLQPEELGLAGAHPLDFLLLDAPLGGPLGLDTLLDGDPAMALKHEERKCPYCPDRFHNGIGLANHVRGHLNRVGVSYNVRHFISAEEVKAIERRFSFQKKKKKVANFDPGTFSLMRCDFCGAGFDTRAGLSSHARAHLRDFGITNWELTVSPINILQELLATSAAEQPPSPLGREPGGPPGSFLTSRRPRLPLTVPFPPTWAEDPGPAYGDAQSLTTCEVCGACFETRKGLSSHARSHLRQLGVAESESSGAPIDLLYELVKQKGLPDAHLGLPPGLAKKSSSLKEVVAGAPRPGLLSLAKPLDAPAVNKAIKSPPGFSAKGLGHPPSSPLLKKTPLALAGSPTPKNPEDKSPQLSLSPRPASPKAQWPQSEDEGPLNLTSGPEPARDIRCEFCGEFFENRKGLSSHARSHLRQMGVTEWYVNGSPIDTLREILKRRTQSRPGGPPNPPGPSPKALAKMMGGAGPGSSLEARSPSDLHISPLAKKLPPPPGSPLGHSPTASPPPTARKMFPGLAAPSLPKKLKPEQIRVEIKREMLPGALHGELHPSEGPWGAPREDMTPLNLSSRAEPVRDIRCEFCGEFFENRKGLSSHARSHLRQMGVTEWSVNGSPIDTLREILKKKSKPCLIKKEPPAGDLAPALAEDGPPTVAPGPVQSPLPLSPLAGRPGKPGAGPAQVPRELSLTPITGAKPSATGYLGSVAAKRPLQEDRLLPAEVKAKTYIQTELPFKAKTLHEKTSHSSTEACCELCGLYFENRKALASHARAHLRQFGVTEWCVNGSPIETLSEWIKHRPQKVGAYRSYIQGGRPFTKKFRSAGHGRDSDKRPSLGLAPGGLAVVGRSAGGEPGPEAGRAADGGERPLAASPPGTVKAEEHQRQNINKFERRQARPPDASAARGGEDTNDLQQKLEEVRQPPPRVRPVPSLVPRPPQTSLVKFVGNIYTLKCRFCEVEFQGPLSIQEEWVRHLQRHILEMNFSKADPPPEESQAPQAQTAAAEAP
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).
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Uniprot ID
Primary ID:
O95785

Secondarily ID:
B3KVH1
B7ZM82
M0QY21
Q4G0E0
Q6P6B0
Q6ZN24
Q7LDY6
Q7LDZ1
Q96IG5
Q96SQ6
Q9BUR8
Q9NPT1
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Ensembl ID
ENSG00000011451
HGNC ID
HGNC:30917
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0953585
 Compound Info 
3-(5-(((R)-1-(4-tert-butylbenzyl)piperidin-2-yl)methoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C30H37N3O4
  1
1
AC50 = 0.083 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0952480
 Compound Info 
3-(1-oxo-5-(((R)-1-(4-(1-(trifluoromethyl)cyclopropyl)benzyl)piperidin-2-yl)methoxy)isoindolin-2-yl)piperidine-2,6-dione
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C30H32F3N3O4
  1
1
AC50 = 0.22 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0962254
 Compound Info 
3-(5-(((R)-1-(4-(3,6-dihydro-2H-pyran-4-yl)benzyl)piperidin-2-yl)methoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C31H35N3O5
  1
1
AC50 = 0.35 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0914643
 Compound Info 
3-(1-oxo-5-(((R)-1-(4-(piperidin-1-yl)benzyl)piperidin-2-yl)methoxy)isoindolin-2-yl)piperidine-2,6-dione
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C31H38N4O4
  1
1
AC50 = 0.37 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0956197
 Compound Info 
3-(5-(((R)-1-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperidin-2-yl)methoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C27H27F2N3O6
  1
1
AC50 = 0.47 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0956196
 Compound Info 
3-(5-(((R)-1-(2,4-dimethoxybenzyl)piperidin-2-yl)methoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C28H33N3O6
  1
1
AC50 = 0.52 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS