General Information of the Protein
Protein ID
PT07141
Protein Name
B-cell lymphoma 3 protein
Secondarily
Protein Name
Proto-oncogene BCL3
Gene Name
BCL3
Secondarily
Gene Name
BCL4
D19S37
Sequence
MPRCPAGAMDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
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Uniprot ID
P20749
Ensembl ID
ENSG00000069399
HGNC ID
HGNC:998
Subcellular Location
Nucleus
Cytoplasm
Cytoplasm
Perinuclear region
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0909593
2-[(2-fluorobenzoyl)amino]-3-methoxy-N-(2-morpholin-4-ylethyl)benzamide
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C21H24FN3O4
 1
1
IC50 = 11.95 nM
   TI
   LI
   LO
   TS
CP0903733
2-[(4-methoxybenzoyl)amino]-N-(2-morpholin-4-ylethyl)benzamide
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C21H25N3O4
 1
1
IC50 = 61.7 nM
   TI
   LI
   LO
   TS
CP0903737
2-fluoro-N-(2-(2-morpholinoethylcarbamoyl)phenyl)benzamide
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C20H22FN3O3
 3
1
IC50 = 156.6 nM
   TI
   LI
   LO
   TS
2
IC50 = 210.6 nM
   TI
   LI
   LO
   TS
3
IC50 = 385.5 nM
   TI
   LI
   LO
   TS
CP0954950
2-[(2-fluorobenzoyl)amino]-N-(pyrrolidin-1-ylmethyl)benzamide
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C19H20FN3O2
 1
1
IC50 = 10410 nM
   TI
   LI
   LO
   TS
CP0903734
2-[(2-fluorobenzoyl)amino]-N-(2-morpholin-4-ylpropyl)benzamide
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C21H24FN3O3
 1
1
IC50 = 15230 nM
   TI
   LI
   LO
   TS