General Information of the Protein
Protein ID
PT07050
Protein Name
Tryptophan 5-hydroxylase 2
Secondarily
Protein Name
Neuronal tryptophan hydroxylase
Tryptophan 5-monooxygenase 2
Gene Name
TPH2
Secondarily
Gene Name
NTPH
Sequence
MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Oxidoreductase
Uniprot ID
Primary ID:
Q8IWU9

Secondarily ID:
A6NGA4
Q14CB0
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Ensembl ID
ENSG00000139287
HGNC ID
HGNC:20692
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000592 , BON
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0302983
 Compound Info 
(S)-2-Amino-3-(4-{2-amino-6-[2,2,2-trifluoro-1-(3'-methylbiphenyl-2-yl)-ethoxy]-pyrimidin-4-yl}-phenyl)propionic acid
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C28H25F3N4O3
  1
1
EC50 = 560 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0191325
 Compound Info 
(S) -2-amino-3-[4-(2-amino-6-[2,2,2-trifluoro-1-(2-(3-trifluoromethyl-pyrazol-1-yl-phenyl)-ethoxy]-pyrimidin-4-yl]-phenyl-propionic acid
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C25H20F6N6O3
  1
1
EC50 = 750 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0344579
 Compound Info 
(2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(2-(furan-2-yl)phenyl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid
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C25H21F3N4O4
  1
1
EC50 = 800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0264690
 Compound Info 
(2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3-(furan-2-yl)thiophen-2-yl)ethoxy)pyrimidin-4-yl) phenyl)propanoic acid
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C23H19F3N4O4S
  1
1
EC50 = 1190 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( L-Tryptophan hydroxylase 2 (TPH2) )
Target Type Literature-reported Target