General Information of the Protein
Protein ID
PT06957
Protein Name
Neuroendocrine convertase 2
Secondarily
Protein Name
KEX2-like endoprotease 2
Prohormone convertase 2
Proprotein convertase 2
Gene Name
PCSK2
Secondarily
Gene Name
NEC2
Sequence
MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Serine protease
>
Serine protease SB clan
>
Serine protease S8B subfamily
Function
Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.
    Show/Hide
Uniprot ID
Primary ID:
P16519

Secondarily ID:
B1ANH9
B4DFQ3
Q14927
Q5JYQ1
Q8IWA8
Q9NQG3
Q9NUG1
Q9UJC6
    Show/Hide
Ensembl ID
ENSG00000125851
HGNC ID
HGNC:8744
Subcellular Location
Cytoplasmic vesicle
Secretory vesicle
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000090 , Schneider 2
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0444278
 Compound Info 
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-6-amino-N-[(4-carbamimidoylphenyl)methyl]hexanamide
   Show/Hide
C51H90N14O8
  1
1
Ki = 0.24 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0433044
 Compound Info 
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-6-amino-N-[(E)-4-(diaminomethylideneamino)but-2-enyl]hexanamide
   Show/Hide
C48H91N15O8
  1
1
Ki = 1.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0097773
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(2S)-1-[(4-carbamimidoylphenyl)methylamino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]decanamide
   Show/Hide
C35H62N12O4
  1
1
Ki = 55 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0130814
 Compound Info 
(2S)-N-[(2S)-1-[[(2S)-1-[(4-carbamimidoylphenyl)methylamino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-5-(diaminomethylideneamino)-2-[(2-phenylacetyl)amino]pentanamide
   Show/Hide
C33H50N12O4
  1
1
Ki = 312 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0192431
 Compound Info 
(S)-2-acetamido-N-((S)-1-((S)-1-(4-carbamimidoylbenzylamino)-5-guanidino-1-oxopentan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-5-guanidinopentanamide
   Show/Hide
C27H46N12O4
  1
1
Ki = 1388 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0192440
 Compound Info 
(S)-5-guanidino-N-((S)-1-((S)-5-guanidino-1-(3-guanidinopropylamino)-1-oxopentan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-2-(2-phenylacetamido)pentanamide
   Show/Hide
C30H53N13O4
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0280631
 Compound Info 
(S)-N-((1-carbamimidoylpiperidin-4-yl)methyl)-5-guanidino-2-((S)-2-((S)-5-guanidino-2-(2-phenylacetamido)pentanamido)-3-methylbutanamido)pentanamide
   Show/Hide
C32H55N13O4
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Neuroendocrine convertase 2 (PCSK2) )
Target Type Literature-reported Target